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このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  3. 研究分野
  5. 生物医学と臨床科学
  7. 心血管医学と血液学
  9. 心臓病 (心血管疾患を含む)
  11. 心臓アミロイドーシスにおけるガドリニウム強化心血管磁気共鳴の予後値

心臓アミロイドーシスにおけるガドリニウム強化心血管磁気共鳴の予後値

Marianna Fontana1, Silvia Pica1, Patricia Reant1

  • 1From Heart Hospital, London, UK (M.F., S.P., P.R., A.A.-G., T.A.T., S.M.B., V.M., S.R., H.B., A.S.H., C.H.M., J.C.M.); Institute of Cardiovascular Science (M.F., A.A.-G., T.A.T., S.M.B., H.B., J.C.M.) and Department of Statistical Science (W.B.), University College London, UK; National Amyloidosis Centre, University College London, Royal Free Hospital, London, UK (M.F., S.M.B., R.H.S., K.P., S.M., C.J.W., H.J.L., A.D.W., J.D.G., P.N.H.); Bristol Heart Institute, University of Bristol, UK (C.B.-D.); University of Pittsburgh School of Medicine, PA (E.B.S.); and National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).

Circulation
|September 13, 2015

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PubMed で要約を見る

まとめ
この要約は機械生成です。

心血管磁気共振におけるトランスムラル遅いガドリニウム増強 (LGE) は,ALおよびATTR型における進行した心臓アミロイドーシスを確実に示す. この発見は 患者の死亡を予測し 既存の要因を超えて 重要な予後情報を提供します

科学分野:

  • 心臓病科
  • 放射線科
  • 医療用イメージング

背景:

キーワード:
アミロイドーシス心臓画像技術磁気共鳴画像検査予後について

関連する実験動画

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

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11.4K
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12:24

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  • 心臓の関与はALとATTRアミロイドーシスの予後に影響を及ぼします.
  • 遅いガドリニウム増強 (LGE) による心血管磁気共振は,心臓アミロイドーシスの診断の鍵です.
  • 心臓アミロイドーシスにおけるLGEのリスク分層の可能性は,ほとんど不明である.

研究 の 目的:

  • 心臓アミロイドーシスのリスクの階層化におけるLGEパターンの役割を評価する.
  • アミロイド負荷の評価のためのLGE技術 (PSIRと大きさのみ) とT1マッピングを比較する.
  • ALとATTRアミロイドーシスの患者の死亡率を予測するかどうかを判断する.

主な方法:

  • 250人の被験者 (122人のATTR,119人のAL,9人のキャリア) はLGE CMRとT1マッピングを受けた.
  • LGEは,相感知逆転回復 (PSIR) と大きさのみによる技術を使用して行われました.
  • フォローアップ期間は平均24ヶ月で,LGEパターンはゼロ,サブエンドカーディアル,またはトランスムラルと分類された.

主要な成果:

  • 細胞外体積 (アミロイド負荷) と相関する,大きさのみと比較して,PSIR LGEが優れている.
  • LGEパターンはゼロからサブエンドカーディアルに,その後はトランスムラルに,細胞外体積が増加した.
  • 既知の予後因子を調整しても,トランスムラルLGEは独立して全因死亡率 (HR 4. 1; P < 0. 05) を予測した.

結論:

  • ALとATTRアミロイドーシスでは心臓の関わりが連続している.
  • PSIRによって信頼性の高いLGEは,進行中の心臓アミロイドーシスを示します.
  • PSIRベースのLGEは,心臓アミロイドーシスの有意なインクリメンタル予後値を提供します.