Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.3K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.3K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

920
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
920
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

893
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
893
Hepatitis01:25

Hepatitis

42
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
42
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

493
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
493
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.1K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Direct Oral Anticoagulant Type and Dose in Atrial Fibrillation With Decompensated Cirrhosis: A Propensity-Matched Analysis.

Gastro hep advances·2026
Same author

Do hepatic and biliary functional data from gadoxetate-enhanced MRI add value in predicting outcomes in primary sclerosing cholangitis (PSC)?

European radiology·2026
Same author

The Nutrition Landscape in Chronic Liver Disease.

Digestive diseases and sciences·2026
Same author

Vitamin B6 predicts poor outcomes in geographically distinct populations with primary sclerosing cholangitis.

Journal of hepatology·2026
Same author

Compositional and functional differences of gut microbiome and metabolome inform pathogenesis of cholestatic liver disease.

Gut microbes·2026
Same author

Gaps in Guideline Adherence for Primary Sclerosing Cholangitis in North America-A 5-Year Analysis.

Liver international : official journal of the International Association for the Study of the Liver·2026

関連する実験動画

Updated: Apr 4, 2026

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

936

主要胆症

Elizabeth J Carey1, Ahmad H Ali1, Keith D Lindor2

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ, USA.

Lancet (London, England)
|September 15, 2015
PubMed
まとめ
この要約は機械生成です。

主要胆症 (PBC) は慢性肝疾患である. ウルソデオキシコール酸 (UDCA) は生存率を向上させるが,反応しない患者には新しい治療法が必要であり,核受容体ホルモンは有望である.

さらに関連する動画

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
12:36

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

18.0K
Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

16.8K

関連する実験動画

Last Updated: Apr 4, 2026

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

936
Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
12:36

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

18.0K
Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

16.8K

科学分野:

  • ヘパトロジー
  • 免疫学
  • 胃腸内科

背景:

  • 主要胆症 (PBC) は,肝臓内の小胆管の自己免疫破壊によって特徴づけられる慢性胆疾患である.
  • 抗ミトコンドリア抗体 (AMA) は,PBC患者の約95%に存在する特定の血清学的マーカーです.
  • 疲労とは,疾患の重度に関係なく,一般的な症状です.

研究 の 目的:

  • PBCの流行病学,病原性,自然史に関する現在の理解をレビューする.
  • PBCの現在の管理戦略と合併症について議論する.
  • 核受容体ホルモンの研究を含む新たな治療法を導入する.

主な方法:

  • 肝硬変に関する既存の文献のレビュー
  • ウルソデオキシコール酸 (UDCA) の有効性に関する臨床試験データの分析
  • 新しい治療目標に関する研究成果の探求

主要な成果:

  • ウルソデオキシコール酸 (UDCA) は,PBC患者の移植なしの生存率を改善しました.
  • PBC患者の約40%がUDCAに対する不十分な生化学反応を示しています.
  • 肝臓移植は不補償性肝硬変の患者に 素晴らしい結果をもたらします

結論:

  • UDCAの利点にもかかわらず,PBC患者の有意な割合は代替治療を必要としています.
  • 核受容体ホルモンの研究は,新しいPBC治療のための有望な道を示しています.
  • PBCの多面的な側面の包括的な理解は,患者のケアを進めるために不可欠です.