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Updated: May 1, 2026

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
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Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Published on: September 14, 2011

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ヒト単細胞における核膜相互作用の全ゲノムマップ

Jop Kind1, Ludo Pagie2, Sandra S de Vries2

  • 1Division of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands; Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Cancer Genomics Netherlands, Uppsalalaan 8, 3584CT Utrecht, the Netherlands.

Cell
|September 15, 2015
PubMed
まとめ

哺乳類の染色体は,核膜とラミナ関連ドメイン (LAD) を形成する. 新しい単細胞マッピングは,一貫した,遺伝子に乏しいLADと,変数,細胞タイプ特有のLADを明らかにし,クロマチンの組織原理を強調しています.

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Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
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The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
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