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Updated: Apr 3, 2026

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BET阻害剤に対する耐性は,白血病幹細胞から発生する

Chun Yew Fong1,2,3, Omer Gilan1,2, Enid Y N Lam1

  • 1Cancer Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

Nature
|September 15, 2015
PubMed
まとめ

ブロモドメインとエクストラ・ターミナル・プロテイン (BET) 阻害剤は急性骨髄性白血病の治療に有望である. レジスタンスは白血病の幹細胞から発生し,部分的にはWnt/β-カテニンのシグナル伝達が増加したため,薬剤の感受性を回復させることが可能である.

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