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アレンのプラチナ触媒によるC-H機能化

Takayuki Furukawa¹, Mamoru Tobisu², Naoto Chatani¹

¹Department of Applied Chemistry, Faculty of Engineering, and ‡Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.

Journal of the American Chemical Society

|September 16, 2015

まとめ

新しいプラチナベースの触媒は,ステリカルに阻害されたアレンのC-Hボリレーションを可能にします. この突破は有機化学の重要な構成要素である有価な2,6-非置換フェニルボロンエステルを合成するための一般的な方法を提供する.

科学分野:

有機化学
カタリシス
合成方法論

背景:

C−H結合の機能化は有機合成において極めて重要です.
アレナにおけるステリカルに阻害された位置は,C-H機能化にとって挑戦的なままです.
メシチレンなどの阻害された基板には,既存の方法の汎用性が欠けている.

研究の目的:

ステリカルに阻害されたアレンのC-Hボリレーションのための一般的な方法を開発する.
アレンC-Hボリレーションのための最初のプラチナベースの触媒を導入する.
価値ある 2,6-非置換フェニルボロンエステルを合成する.

主な方法:

プラチナベースの新しい触媒の開発.
C-H ボリル化反応の触媒の適用
合成されたフェニルボロンエステルの特徴.

主要な成果:

プラチナ触媒はステリック阻害に対する高い耐性を示した.
2,6-非置換フェニルボロンエステルの一連の迅速なアクセスは達成された.
この方法はアレンとヘテロアレンの両方に有効であることが証明された.

結論:

ステリカルに阻害されたアレンのC-Hボリレーションのための一般的で効率的な方法が確立されています.
開発されたプラチナ触媒は,合成有機化学の重要な進歩です.
合成されたフェニルボロンエステルは,さらなる化学的変換のための多用途な構成要素として機能する.

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