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In Vitro Analysis of E3 Ubiquitin Ligase Function
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ユービキチン・リゲーゼをプロシシブからディストリビューティブの酵素メカニズムに切り替える小分子

Stefan G Kathman1, Ingrid Span1, Aaron T Smith1

  • 1Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Department of Chemistry, Department of Molecular Biosciences, Northwestern University , Silverman Hall, 2145 Sheridan Road, Evanston, Illinois 60208, United States.

Journal of the American Chemical Society
|September 16, 2015
PubMed
まとめ

研究者らは,E3リガゼNedd4-1のプロセシビティを突然変異または小分子を使って切り替えることで,そのメカニズムが変化することを発見しました. この発見は,様々な疾患に対する標的型E3リガース阻害剤の開発の新しい戦略を示しています.

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