中性粒子の老化は 微生物群によって制御される
Dachuan Zhang1,2, Grace Chen1,2, Deepa Manwani3
1Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Nature
|September 17, 2015
まとめ
微生物群は 中性粒子の老化を促し 炎症性疾患を悪化させる 過度に活発なサブセットを生み出します 腸内微生物の減少は 老化中の中性粒子を大幅に減少させ,シークル細胞病とセプティックショックのモデルにおいて 疾患の結果と臓器損傷を改善する.
科学分野:
- 免疫学
- 微生物学
- 血液学
背景:
- 中性粒子は重要な免疫細胞ですが,炎症で組織損傷を引き起こす可能性があります.
- 証拠によると,中性粒子は均質な集団ではなく,老化によって異質性が生じる可能性がある.
- 老いた中性粒子はCXCR4のアップレギュレーションとL-セレクチン発現の減少を含む独特の特徴を示します.
研究 の 目的:
- ニュートロフィルの老化の役割を in vivoで調査する.
- 炎症中の老いた中性粒子の機能的性質を決定する.
- 中性粒子の老化を制御する要因とその病気への影響を特定する.
主な方法:
- マウスモデルでのin vivo老化分析
- 中性粒子の活性化マーカー (例えば,αMβ2インテグリン) と中性粒子の細胞外トラップ (NET) 形成の評価.
- ミクロビオタの枯渇戦略と,状細胞疾患とセプティックショックのモデルにおける病原性の評価.
主要な成果:
- 中性粒子の炎症誘発性活動は,血液循環年齢とともに増加する.
- 老いた中性粒子はαMβ2インテグリン活性化とNET形成が強化されている.
- 微生物群は,Tollのような受容体とミエロイド分化因子88の信号伝達によって中性粒子の老化を誘導する.
- 微生物群の枯渇は老いた中性粒子を減少させ,病気のアウトカムを改善しました.
結論:
- 循環中の中性粒子の老化は,炎症促進機能を高めます.
- 腸内微生物群は 病気を誘発する老化中性粒子のサブセットを駆動する上で 重要な役割を果たします
- 微生物群を標的とした治療は,中性粒子の誘発による炎症や臓器損傷を軽減するための治療策である.
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