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Updated: Apr 3, 2026

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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Caspase-11は,非正規の炎症体シグナル伝達のためにガスダーミンDを割る

Nobuhiko Kayagaki1, Irma B Stowe1, Bettina L Lee1

  • 1Department of Physiological Chemistry, Genentech Inc., South San Francisco, California 94080, USA.

Nature
|September 17, 2015
PubMed
まとめ

ガスダーミンD (GSDMD) は,グラム陰性細菌感染後のカスパーゼ""誘発の熱中症とインタールキン"βの放出に不可欠です. カスパース-11によるGSDMDの活性化は,致命的な細菌性毒に対する宿主防御を媒介する.

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