双極性障害

Iria Grande¹, Michael Berk², Boris Birmaher³

¹Bipolar Disorders Unit, Clinical Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.

Lancet (London, England)

|September 22, 2015

まとめ

双極性障害は世界全体の 1%以上に影響を与え障害や死亡率を引き起こします診断上の課題とバイオマーカーの欠如のために,低狂気のエピソードに焦点を当てた臨床評価は,正確な診断に不可欠です.

科学分野:

精神科と精神保健
神経科学
臨床医学

背景:

双極性障害は慢性的な再発性気分障害で世界人口の1%以上に影響します
認知障害,機能的欠陥,自殺を含む死亡率の増加と関連して,若い成人の障害の主な原因です.
双極性障害の患者に高い割合の精神疾患や併発性疾患が共通している.

研究の目的:

双極性障害を特定する際の診断上の課題を強調し,特に単極性うつ病と区別する.
正確な診断において,低狂気のエピソードと縦断的な評価の検出を含む臨床評価の重要な役割を強調する.
双極性障害の現在の薬理学的および心理学的治療戦略を理解することの重要性を強調する.

主な方法:

双極性障害の臨床表現と診断基準のレビュー
流行と影響に関する疫学データの分析
現在の診断課題と臨床評価の役割の検討
既存の治療方法と進化する治療方法の議論

主要な成果:

正確な診断はしばしば遅れます双極性障害は一般的にうつ病のエピソードで,単極性うつ病を模倣します
検証されたバイオマーカーがないため,徹底した臨床評価が必要である.
長期的評価と低狂気期の識別は,差異診断に不可欠です.

結論:

縦断的な追跡とヒポマニアの検出を含む臨床的評価は,双極性障害の診断に極めて重要です.
有効なバイオマーカーに関するさらなる研究が必要である.
この複雑な状態の管理には進化する治療戦略の認識と適用が不可欠です

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