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関連する概念動画

Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

6.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.8K
Regulation of Food Intake01:30

Regulation of Food Intake

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.2K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
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Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

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Hypodermis01:02

Hypodermis

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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関連する実験動画

Updated: Apr 3, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
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Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

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レプチンによる脂肪に対する共感的な見方

Luis Varela1, Tamas L Horvath1

  • 1Program in Integrative Cell Signalling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

Cell
|September 26, 2015
PubMed
まとめ

レプチン

科学分野:

  • 内分泌学
  • 神経科学
  • 脂肪組織生物学

背景:

  • レプチンは エネルギーバランスと体重を 調節する重要なホルモンです
  • レプチン抵抗は肥満の特徴であり,代謝効果を損なう.
  • レプチンの脂解作用を媒介する正確なメカニズムはまだ研究中です.

研究 の 目的:

  • 白い脂肪細胞にレプチンの脂解作用を媒介する直接的な神経経路を調査する.
  • 中央レプチン抵抗を克服するために,局所的な共感入力をターゲットにする可能性を調査する.

主な方法:

  • 白い脂肪細胞の 交感神経繊維の内置を視覚化するために 先進的なイメージング技術を使用しました
  • 脂肪組織における共感活性を操作する薬理学的および遺伝的ツールを使用した.

主要な成果:

  • 交感性神経繊維が 白い脂肪細胞に 直接接着していることが示されました
  • レプチンの脂質分解効果を模倣し媒介することを示した.
  • 脂肪組織へのレプチンの信号を 直接接続する神経回路を特定した

結論:

  • 交感神経繊維は,レプチンの脂解作用の重要な媒介です.

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Last Updated: Apr 3, 2026

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Isolation of Adipose Tissue Immune Cells
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  • 脂肪組織の局所的な共感内置をターゲットにすることで 中央レプチン抵抗を回避することで 肥満と闘う新しい戦略が提供されます