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SERINC3とSERINC5はHIV-1の感染性を制限し,Nefによって抑制されます

Yoshiko Usami1, Yuanfei Wu1, Heinrich G Göttlinger1

  • 1Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Nature
|September 30, 2015
PubMed
まとめ

ヒト免疫不全ウイルス1型 (HIV-1) のネフタンパク質とマウス白血病ウイルスのグリコガは,SERINC3とSERINC5のタンパク質をビリオンに組み込むことを防ぐことでウイルス感染性を低下させます. この発見はHIV/エイズと闘うための戦略を提示しています

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