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メディエーターキナーゼ阻害は,AMLにおけるスーパーエンハンサー関連遺伝子をさらに活性化します

Henry E Pelish1, Brian B Liau1, Ioana I Nitulescu1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Nature
|September 30, 2015
PubMed
まとめ

介介キナーゼCDK8とCDK19は,急性骨髄性白血病 (AML) のスーパーエンハンサー (SE) 遺伝子活性化を抑制する. コルチスタチンAはこれらのキナーゼを抑制し,SE遺伝子を上調し,AML細胞に抗白血病効果を示します.

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