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Updated: Apr 2, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

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血管の滑らかな筋肉細胞の老化は,動脈硬化とプラークの脆弱性の特徴を促進する

Julie Wang1, Anna K Uryga1, Johannes Reinhold1

  • 1From Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

Circulation
|September 30, 2015
PubMed
まとめ

動脈硬化における血管滑らかな筋肉細胞 (VSMC) の衰老は,TRF2 (テロメア再結合因子-2) によってテロメアの保護が低下するとの関連がある. TRF2の損失は動脈硬化とプラークの脆弱性を加速し,老化の予防を治療目標として示唆しています.

キーワード:
老化する動脈硬化症筋肉 滑らか血管疾患

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