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Updated: Apr 1, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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Cpf1は,クラス2のCRISPR-Casシステムの単一のRNA誘導内核酶である

Bernd Zetsche1, Jonathan S Gootenberg2, Omar O Abudayyeh3

  • 1Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Developmental Pathology, Institute of Pathology, Bonn Medical School, Sigmund Freud Street 25, 53127 Bonn, Germany.

Cell
|October 1, 2015
PubMed
まとめ

研究者らは,Cpf1という新しいクラス2のCRISPR- Casエフェクタータンパク質を特定しました. このRNA誘導内核酵素は 独特のDNA分裂メカニズムを提供し CRISPR技術を拡張する 人間の細胞における効率的なゲノム編集を示しています

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