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Neuronal Nuclei Isolation from Human Postmortem Brain Tissue
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単一の人間のニューロンの体内変異は,発達と転写の歴史を追跡する

Michael A Lodato1, Mollie B Woodworth1, Semin Lee2

  • 1Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA; and Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Science (New York, N.Y.)
|October 3, 2015
PubMed
まとめ

ニューロンは,複製エラーではなく,転写に関連した損傷により,数千の体内単核酸変異 (SNV) を蓄積する. これらの変異は人間の脳皮質を明らかにします

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