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関連する概念動画

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

14.5K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
14.5K
Olfaction01:25

Olfaction

49.9K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
49.9K
The Central Dogma01:25

The Central Dogma

145.2K
Overview
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The Central Dogma01:20

The Central Dogma

35.3K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
35.3K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

14.1K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
14.1K
From DNA to Protein03:06

From DNA to Protein

24.5K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
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関連する実験動画

Updated: Apr 1, 2026

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor
11:26

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor

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吐口鼻系 の 識別 器 の 分子 コード

Xiaoyan Fu1, Yuetian Yan2, Pei S Xu1

  • 1Department of Anatomy and Neurobiology, Washington University in St. Louis, St. Louis, MO 63110, USA.

Cell
|October 6, 2015
PubMed
まとめ

研究者らは,コンポーネント・アクティビティ・マッチング (CAM) を用いてマウスの尿に含まれる主要な嗅覚信号を特定した. この方法により 哺乳類の嗅覚伝達や 社会的行動に不可欠な 新種のステロイドカルボキシル酸が 発見されました

さらに関連する動画

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
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Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

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In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ
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In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

8.2K

関連する実験動画

Last Updated: Apr 1, 2026

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor
11:26

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor

Published on: December 6, 2011

11.3K
Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
06:32

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

Published on: June 5, 2017

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In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ
10:11

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

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科学分野:

  • 哺乳類の嗅覚
  • 神経倫理学
  • 化学エコロジー

背景:

  • 哺乳類の社会的なやり取りは 個人の認識のための 嗅覚のシグナルに依存しています
  • 複雑な香水混合物内の特定のシグナリング化合物を特定することは大きな課題です.

研究 の 目的:

  • 複雑な混合物から主要な嗅覚リガンドを識別するための新しい方法を開発する.
  • マウスの社会的嗅覚コミュニケーションの分子基盤を特徴づける.

主な方法:

  • 化学化合物を神経活動パターンと結びつけるために,コンポーネント・アクティビティ・マッチング (CAM) を開発した.
  • 8種類のマウスの尿を分析した.
  • 嗅覚神経細胞の活動が記録された

主要な成果:

  • 8つのボメロナス感覚ニューロンクラスのうち7つの活動を説明する23の候補リガンドを特定した.
  • ステロイドカルボキシル酸が女性特有の新種の口鼻リガンドとして発見された.
  • 女性の香りに対する 男性の調査行動と 登山行動に影響を及ぼすことが示されました

結論:

  • コンポーネント・アクティビティ・マッチング (CAM) は,行動的に関連する嗅覚リガンドを特定するのに有効です.
  • ステロイドカルボキシル酸はマウスの社会的嗅覚伝達において重要な役割を果たします.
  • この研究は哺乳類の嗅覚における 分子信号の特徴づけを進めている.