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身体活動と心不全のリスクとの投与量反応関係:メタ分析

Ambarish Pandey¹, Sushil Garg¹, Monica Khunger¹

¹From Division of Cardiology (A.P., C.A., D.J.K., J.A.d.L., J.D.B.), Department of Internal Medicine (D.D.), and Department of Clinical Sciences (C.A., J.D.B.), University of Texas Southwestern Medical Center, Dallas; Department of Internal Medicine, University of Minnesota School of Medicine, Minneapolis (S.G.); Department of Internal Medicine, Cleveland Clinic, OH (M.K.); and University of Texas Southwestern Medical Center Library, Dallas (H.G.M.).

|October 7, 2015

まとめ

定期的な身体活動 (PA) は,心不全 (HF) のリスクを有意に低下させる. 最低基準を超えたPAレベルは,HFの発生に対してより高い保護を提供します.

科学分野:

心臓病科
予防医学
公衆衛生

背景:

以前の研究では,身体活動 (PA) と心不全 (HF) のリスクとの間には逆の関係があることが示されています.
以前は,この用量反応関連性に関する包括的な定量分析が欠けていました.

研究の目的:

身体活動 (PA) と心不全 (HF) リスクの量的な用量反応関係を評価するメタ分析を行う.
異なるレベルのPAが発生したHFに与える影響を測定する.

主な方法:

12件の前向きなコホート研究の体系的レビューとメタ分析.
含有基準: 参加者18歳以上,ベースラインのPAとインシデントHFが報告されました.
ランダム効果と一般化された最小二乗回帰モデルを用いた分析

主要な成果:

この研究には370,460人の参加者が含まれて,20,203件のHFイベントが報告されました.
最も高いPA濃度では,HFリスクの総合リスク比率が0. 70 (95%CI,0. 67- 0. 73) であった.
ガイドラインの最低値の2倍と4倍 (1000および2000MET/ min/ week) のPAは,実質的なリスク低下を示した (HRはそれぞれ0. 81および0. 65).

結論:

身体活動と心不全のリスクは逆の量反応関係にある.
最低のPAガイドラインを上回ることは,HFのリスクをより大幅に減らすことに関連しています.
心不全のリスクの大幅な軽減には,より高い身体活動レベルが不可欠です.

キーワード:

運動する心不全メタ解析予防と対策

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