REM睡眠の制御は,腹中髄のGABAergicニューロンによって行われます
Franz Weber1, Shinjae Chung1, Kevin T Beier2
1Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA.
Nature
|October 8, 2015
まとめ
研究者達は 眼の急速な動き (REM睡眠) を促進する GABAergic経路を 腹中髄から発見しました この 神経細胞 を 活性化 さ せる と,REM 睡眠 が 生じ,脳幹 の 重要な 部分 が 明らか に なる
科学分野:
- 神経科学
- 睡眠科学
- 神経生物学
背景:
- 急速眼球運動 (REM) 睡眠は 記憶の強化と 感情の調節に不可欠な脳の状態です
- 脳の幹,特にポンは,レム睡眠を生成することが知られていますが,髄膜の役割はあまり理解されていません.
- GABAergic (γ-アミノバチル酸を放出する) ニューロンは阻害性であり,ニューロン活動とネットワーク状態の調節に重要な役割を果たします.
研究 の 目的:
- REM睡眠の生成における腹中髄ニューロンの因果的役割を調査する.
- REM睡眠を制御する 神経経経路を特定する
- 脳の幹内の これらの経路の 機能的な接続性を調べるため
主な方法:
- マウスの特定の腹中髄GABAergicニューロン集団の光遺伝的操作.
- 睡眠状態とニューロンの活動を 関連付けるための記録です
- ニューロンのプロジェクションをマッピングする
主要な成果:
- REM睡眠エピソードを確実に誘発し,延長した.
- これらのニューロンの不活性化により REM睡眠が抑制されました
- これらのニューロンは,レム睡眠 (REMmax) 時に最大限の活動を示し,食事やケージングの間も活発でした.
- 腹中髄から分離したロストラル・プロジェクションと尾のプロジェクションが特定され,ロストラル・プロジェクションはレム睡眠の誘導と維持に十分であった.
結論:
- 腹中髄からのGABAergic経路は,レム睡眠の強力な促進剤です.
- この経路は REM睡眠の制御を ポーンと中脳への投影を通して行います
- これらの発見は,レム睡眠を調節する ポントメドゥラーネットワークの 重要な構成要素を特定します
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