一般医療におけるニコチン対プラセボガムの比較
J R Hughes1, S W Gust, R M Keenan
1Department of Psychiatry, University of Vermont, Burlington.
JAMA
|March 3, 1989
まとめ
ニコチンガムは,一般診療の環境で,禁煙に最小限の効果を示した. ニコチンガムやプラセボガムを受けた喫煙者は,11ヶ月後に同様の禁煙率を示した.
科学分野:
- 依存症医学 薬物中毒医学
- 公衆衛生は公衆衛生である.
- 一般的実践について
背景:
- 禁煙の介入は,公衆衛生にとって極めて重要です.
- ニコチン置換療法 (NRT) は,一般的な禁煙補助薬です.
- 多様で未選択の集団におけるNRTの有効性は評価が必要です.
研究 の 目的:
- 禁煙のためのニコチンガムの効果とプラセボガムの効果を評価するために.
- 短期的な介入による一般医療の環境におけるニコチンガムの影響を評価する.
主な方法:
- 315人の喫煙者が参加したランダム化,ダブルブラインド,プラセボ対照試験.
- 参加者は,医師/看護師の短いアドバイス,教育資料,および1回のフォローアップ訪問を受けました.
- 介入は,2mgのニコチンガムまたはプラセボガムによるものであった.
主要な成果:
- 11ヶ月後,ニコチンガム群の10%とプラセボ群の7%が,継続的な禁欲を検証した.
- ニコチンとプラセボのグループ間の禁欲率の違いは統計的に有意ではなかった.
- 婚姻状況と収入を調整しても,結果は変わらなかった.
結論:
- ニコチンガムは,この未選択の喫煙者グループでは,禁煙のための追加の利益がほとんどないか全くなかった.
- 一般診療におけるニコチンガムと組み合わせた短期的な介入は,禁煙率を著しく向上させない場合があります.
- ニコチンガムからより多くの恩恵を受ける特定のサブグループを特定するために,さらなる研究が必要になる可能性があります.
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