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Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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セストリン2はmTORC1経路のためのルイシンセンサーです

Rachel L Wolfson1, Lynne Chantranupong1, Robert A Saxton1

  • 1Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, MA 02142, USA. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|October 10, 2015
PubMed
まとめ

ルシンはセストリン2と結合してmTORC1経路を活性化し,GATOR2との相互作用を妨げます. この結合は,レウシンが成長をシグナル化するために不可欠であり,Sestrin2を重要なレウシンセンサとして識別します.

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