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Updated: Apr 1, 2026

Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System
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NLRC4の誘発性自己増殖の構造的および生化学的基礎

Zehan Hu1, Qiang Zhou2, Chenlu Zhang1

  • 1Ministry of Education Key Laboratory of Protein Science, Center for Structural Biology, School of Life Sciences, Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China.

Science (New York, N.Y.)
|October 10, 2015
PubMed
まとめ

核酸結合ドメインとレウシンに富んだリピートタンパク質 (NLR) は,先天的な免疫のための炎症体を形成する. この研究は,NAIP-NLRC4炎症体構造を明らかにし,NLRC4の活性化と自己拡散メカニズムを詳細に説明しています.

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