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Updated: Apr 1, 2026

Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy
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Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy

Published on: February 17, 2023

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電子冷凍顕微鏡で検出されたInsP3Rチャネルのゲート装置

Guizhen Fan1, Matthew L Baker2, Zhao Wang2

  • 1Department of Biochemistry and Molecular Biology, Structural Biology Imaging Center, The University of Texas Medical School at Houston, 6431 Fannin Street, Houston, Texas 77030, USA.

Nature
|October 13, 2015
PubMed
まとめ

研究者らは,カルシウムシグナル伝達に不可欠なイノシトール-1,4,5-トリフォスファート受容体 (InsP3Rs) の近原子構造を明らかにした. 独特の螺旋構造は これらの重要なイオンチャネルを 制御する新しいメカニズムを示唆しています

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