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熱ショック反応のトランスレーション制御を指示するダイナミック m(6) A mRNAメチル化

Jun Zhou1, Ji Wan1, Xiangwei Gao1

  • 1Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

Nature
|October 13, 2015
PubMed
まとめ

熱ショックストレスは,mRNA 5'未翻訳領域 (5'UTRs) のN(6) -メチラデノシン (m(6) A) 変異を誘発する. このダイナミックなメチル化により,キャップ独立変換が促進され,ストレス反応が強化されます.

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