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Visualization of ATP Synthase Dimers in Mitochondria by Electron Cryo-tomography
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Published on: September 14, 2014

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500kDaの酵母アセチル-CoAカルボキシラーゼホロ酵素二重体の結晶構造

Jia Wei1, Liang Tong1

  • 1Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

Nature
|October 13, 2015
PubMed
まとめ

Saccharomyces cerevisiae Acetyl-CoA carboxylase (ScACC) ホロ酵素の結晶構造は,そのユニークな構造と触媒機構を明らかにしています. この発見は 脂肪酸の代謝や 糖尿病や癌などの 潜在的薬物の標的について 洞察力を与えてくれます

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ATP Synthase: Structure01:18

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ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
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Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
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In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
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The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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