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Updated: Nov 4, 2025

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逆説的なMAPK経路の活性化を回避するRAF阻害剤

Chao Zhang1, Wayne Spevak1, Ying Zhang1

  • 1Plexxikon Inc., 91 Bolivar Drive, Berkeley, California 94710, USA.

Nature
|October 16, 2015
PubMed
まとめ

次世代のRAF阻害剤,または"パラドックスブレーカー"は,パラドックス経路の活性化なしに,BRAF変異によって引き起こされる癌の成長を効果的に抑制します. これらの新薬は,第一世代のRAF阻害剤と比較して,有効性が向上し,耐性を克服しています.

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