リンパ球の移動を制御する粘着分子は,リンパ球の移動を制御する粘着分子を制御します.
1Department of Pathology University of Michigan, Ann Arbor 48109-0602.
Cell
|March 24, 1989
まとめ
Hermes/CD44とMel-14という2つの粘着分子ファミリーは,リンパ性細胞と血管の相互作用を媒介する. メル14 メル14 メル14
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
背景:
- 循環するリンパ性細胞は,粘着分子を介して血管壁と相互作用します.
- インテグリンと免疫グロブリンスーパーゲンファミリーは,この相互作用のメディエーターとして知られています.
研究 の 目的:
- 粘着分子の新たに特定された構造家族を特徴づける.
- リンパ球再循環と粘着イベントにおけるそれらの役割を調査する.
主な方法:
- 粘着分子ファミリーの構造分析 (ハーメス/CD44,Mel-14).
- 既知のタンパク質構造 (軟骨結合タンパク質,レクチン,EGF,コンプリメント結合タンパク質) とのシーケンスホモロジーの比較.
主要な成果:
- 特定されたヘルメス/CD44ファミリー,軟骨結合タンパク質と同型で,血管床への結合に関与しています.
- メル14受容体とレクチン,EGF,そしてコンプリメント結合タンパク質ドメインを特徴付け,リンパ球ホーミングにおけるレクチン-炭水化物相互作用をサポートしています.
- この構造家族をELAM-1とGMP-140に拡張し,白血球と血小板の粘着に関与させた.
結論:
- 2つの新しい粘着分子ファミリーは,白血球-血管壁の相互作用において重要な役割を果たします.
- レクチン-炭水化物の相互作用は,リンパ球再循環において有意である.
- この発見は,免疫細胞の密輸における粘着メカニズムについての理解を広げています.
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