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Updated: Mar 31, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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CRISPR-CasシステムにおけるPAM依存スペーサー取得の構造とメカニズムの基礎

Jiuyu Wang1, Jiazhi Li2, Hongtu Zhao2

  • 1Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Cell
|October 20, 2015
PubMed
まとめ

細菌はCRISPR-Casシステムを使って ウイルスのDNAを記憶します この研究は,Cas1-Cas2複合体の構造を明らかにし,免疫記憶のためのCRISPR配列にウイルスDNA断片 (スペーサー) を選択して挿入する方法を示しています.

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