分裂および芽生える酵母におけるミトーシス制御の保存

P Russell¹, S Moreno, S I Reed

¹Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.

Cell

|April 21, 1989

まとめ

この研究では,分裂酵母が分裂酵母であることを発見しました.

科学分野:

細胞生物学細胞生物学
分子生物学は分子生物学である.
遺伝学遺伝学とは

背景:

ミトーシスの開始は,相反するミトーシス誘発剤と阻害剤によって調節されます.
ユカリオット全体でこの制御ネットワークの保全を理解することは極めて重要です.

研究の目的:

発芽酵母 (S. cerevisiae) で同様のミトーシス制御ネットワークが機能しているかどうかを調査する.
分裂酵母 (S. pombe) のミトーシス制御システムの保存を決定するために.

主な方法:

S. cerevisiae.における発現した分裂酵母 wee1+遺伝子.
cdc25+の同型であるS. cerevisiae MIH1遺伝子を特定し,特徴づけました.
ミヒ1-S. cerevisiae菌株における wee1+発現の影響を研究した.

主要な成果:

分裂酵母ウィー1+は,S. cerevisiaeで発現するとミトーシスの開始を遅らせます.
S. cerevisiae MIH1は,ミトーシス誘導体として作用し,wee1+の活性に対抗する.
ミヒ1菌株における wee1+ 発現は,S. cerevisiaeにおけるミトーシスの開始を防ぐ.

結論:

S. pombe cdc25+-wee1+ミトーシス制御ネットワークの重要な特徴は,S. cerevisiaeに保存されています.
これは,eukaryotic mitotic制御メカニズムの一般的な保存を示唆しています.

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