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Updated: Mar 31, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
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ヴィニロゲスエノラートによるパラジウム触媒の炭素結合:スタチン構造への適用

Ilya S Makarov1, Takashi Kuwahara1,2, Xavier Jusseau1

  • 1Carbon Dioxide Activation Center (CADIAC), The Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University , Gustav Wieds Vej 14, 8000 Aarhus, Denmark.

Journal of the American Chemical Society
|October 24, 2015
PubMed
まとめ

この研究では,ヴィニロゲスなエノラートを用いて最初のパラジアム触媒化されたカルボニラティブカップリングを導入し,ガンマ位置でのC-C結合形成を独占的に達成しました. この新しい方法は,穏やかな条件下でスタチン前駆物質の効率的な合成を可能にします.

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