分割された注意の感覚選択のタラミック制御
Ralf D Wimmer1, L Ian Schmitt1, Thomas J Davidson2
1New York University Neuroscience Institute, Department of Neuroscience and Physiology, New York University Langone Medical Center, New York, New York 10016, USA.
Nature
|October 28, 2015
まとめ
脳は皮質下回路をバイアスして 感覚情報を選択します 前頭前皮質 (PFC) は視覚タラミック網膜核 (visTRN) に影響し,感覚の獲得と注意を制御する.
科学分野:
- 神経科学
- 認知神経科学
- システム神経科学
背景:
- 前頭前皮質 (PFC) は,注意と感覚選択を含む執行機能に関与しています.
- 脳が関連する感覚情報を選択し 気を散らすものを無視する 精密な神経回路は ほとんど不明です
- PFCと感官皮質領域の相互作用は,注意の間に感官の選択を媒介すると仮定されている.
研究 の 目的:
- 交差感受性選択の基礎となる神経機構を調査する.
- 感覚刺激に対する注意を制御する 前頭前皮質 (PFC) 相互作用の役割を決定する.
- 特定の感覚インプットの優先順位に 関わる皮質下回路を解剖する.
主な方法:
- マウスのクロスモダル分断注意のタスクの開発
- 注目作業中のPFC機能の光遺伝的障害
- 電気生理学と細胞内クロライド光学で 神経活動を研究する.
- 視界タラミック網膜核 (visTRN) の双方向的な光遺伝的操作
主要な成果:
- PFCによる干渉は 視覚的刺激と 聴覚的刺激の対立を 選択する能力を損ねました
- 行動的欠陥はPFCと感知性タラムスの相互作用に依存し,感知性皮質ではない.
- 視覚タラミック網膜核 (visTRN) のニューロンは,選択された様式を予測するPFC依存の発火速の変化を示した.
- visTRNの活動は,タスクのパフォーマンスと因果的に結びついていた.
結論:
- 前頭前皮質 (PFC) は,皮質下回路をバイアスすることによって,感覚選択において重要な役割を果たします.
- 感覚選択の新しい皮質下モデルが提案され,タラミック網状子ネットワークのPFC調節が含まれています.
- visTRNは,フィードフォワードの阻害によってタラミック感覚の獲得を動的に制御し,それによって適切な感覚の入力を選択します.
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