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Updated: Mar 31, 2026

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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C-Jun N-ターミナルキナーゼ3のゲートキーパーMET146をターゲットに,バイバルハロゲン/カルコゲン結合を誘導する

Andreas Lange1,2, Marcel Günther3, Felix Michael Büttner4

  • 1Molecular Design and Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.

Journal of the American Chemical Society
|October 28, 2015
PubMed
まとめ

薬剤設計におけるハロゲン結合は,親和性が増加しない場合でも,c- Jun N- 末端キナーゼ3 (JNK3) 阻害剤の選択性を高めることができます. この研究は,特定のハロゲン選択が より良い薬の開発のために 独特のキナーゼ特性をターゲットにする方法を強調しています.

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