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Updated: Mar 30, 2026

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
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α-ケトグルタレット依存型単核非ヘム鉄酵素によるエンドペロキシド形成

Wupeng Yan1, Heng Song2, Fuhang Song3

  • 1Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, USA.

Nature
|November 3, 2015
PubMed
まとめ

研究者らは,非ヘム鉄酵素であるAspergillus fumigatus fumitremorgin Bエンドペロキシダース (FtmOx1) によってエンドペロキシド形成の新たなメカニズムを発見した. 主要なチロシン残基は活性部位をシールドし,ヒドロキシル化ではなくエンドペロキシド合成に触媒を向けます.

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