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TET媒介による酸化に対する基質の好みに関する構造的洞察

Lulu Hu1,2,3, Junyan Lu4, Jingdong Cheng1,2

  • 1Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.

Nature
|November 3, 2015
PubMed
まとめ

10−11 転位 (TET) タンパク質はDNAメチル化を酸化する. TET1とTET2は,基質構成と酸化効率により,5-ヒドロキシメチルシトシン (5hmC) または5-ホルミルシトシン (5fC) よりも,5メチルシトシン (5mC) に高い活性を示しています. これは5hmCが 安定した表遺伝子マークであることを示唆しています

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