ヒルズチズムに対する介入
Esther J van Zuuren1, Zbys Fedorowicz2
1Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands.
JAMA
|November 4, 2015
まとめ
軽度のヒルスチズムでは,経口避妊薬 (OCP) が改善します. フルタミドやスピロノラクトンはより重症な症例に効果があるが,フィナステリド,GnRH類,メトホルミンはヒルシウト症の治療に限られた効果を示している.
科学分野:
- 内分泌学
- 薬理学について
- 皮膚科
背景:
- 女性に男性型毛が生えすぎることが特徴であり,生活の質に大きな影響を与えます.
- この状態の管理に有効で安全な治療法を特定することが不可欠です.
研究 の 目的:
- ヒルシュア症に対する様々な治療法の有効性と安全性を評価する.
- 最低の副作用で 最も有益な治療法を見極めるため
主な方法:
- 臨床試験の体系的レビューとメタ解析
- ヒルシュート症の治療結果の比較分析
主要な成果:
- 口服避妊薬 (OCP) は,軽度のヒルシュート症の治療に有効であることが示されました.
- フラタミド (250 mg BID) とスピロノラクトンは,より重度のヒルスチズムに有効でした.
- フィナステリドとゴナドトロピンを放出する同類薬は不一致な結果をもたらした.
- メトホルミンは有意な利益と関連付けられませんでした.
結論:
- OCPは軽度のヒルシュート症の主要な治療法です.
- フラタミドとスピロノラクトンは中等から重度のヒルシュティズムに推奨されます.
- フィナステリドとGnRHアナログの役割を明確にするためにさらなる研究が必要です.
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