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関連する概念動画

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

15.6K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
15.6K
Bone Disorders01:29

Bone Disorders

7.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.6K
Compact Bone01:27

Compact Bone

20.7K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
20.7K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

13.8K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
13.8K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

9.4K
9.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.7K

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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

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オステオゲネシス・インパーフェクト

Antonella Forlino1, Joan C Marini2

  • 1Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.

Lancet (London, England)
|November 7, 2015
PubMed
まとめ
この要約は機械生成です。

オステオゲネシス・インパーフェクトは 遺伝性疾患のグループで コラーゲンやその他のタンパク質の欠陥により 骨が脆くなります 最近の発見により 多様な遺伝的原因が明らかになり 骨の脆弱性に対する理解と 治療の可能性が向上しています

さらに関連する動画

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
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Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

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Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
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Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

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関連する実験動画

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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

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Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
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Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

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Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
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Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

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科学分野:

  • 遺伝学
  • 生物化学
  • 整形外科

背景:

  • オステオゲネシス・インパーフェクト (OI) は,異質な遺伝性結合組織疾患である.
  • 骨格の異常,骨の脆さ,そして変形によって特徴付けられる.
  • 以前は主にタイプIのコラーゲン欠陥と 関連付けられていたが 最近の発見は より広範な遺伝的原因を示している.

研究 の 目的:

  • オステオゲネシス・インパーフェクトの原因を 調べるためだ
  • そのメカニズム,相互関係,分類を調査する.
  • 診断,管理,治療戦略について話し合います.

主な方法:

  • OI遺伝学の最近の発見の文献レビュー
  • 原因遺伝子の分析とタンパク質の機能
  • OIの分類は,メタボリック経路の障害に基づいています.

主要な成果:

  • 構造性,酵素性,輸送性,およびシャパロン性タンパク質を含む,タイプIコラーゲン以外の様々な原因遺伝子を特定した.
  • コラーゲンに関連する病理生理学が 主に支持され,より広範な意味を持つ.
  • OIの欠陥を研究することで正常な骨発達の理解を深める.

結論:

  • 特定の分子基盤の知識は,OIの臨床診断と標的治療の進歩に不可欠です.
  • 代謝経路に基づいて5つのグループに分類することは理解を助ける.
  • OIの管理,診断,治療の全体的なアプローチは不可欠です.