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Updated: Mar 30, 2026

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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53BP1とLINC複合体は,微小管に依存するDSBの移動性とDNA修復を促進する

Francisca Lottersberger1, Roos Anna Karssemeijer1, Nadya Dimitrova1

  • 1Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

Cell
|November 7, 2015
PubMed
まとめ

DNA二重鎖断裂 (DSB) の移動性は53BP1,LINC複合体,およびマイクロチューブルによって制御される. この動きは健康な細胞の DNA 修復を助けますが,DNA 損傷が広範囲に及ぶ場合,エラーを引き起こす可能性があります.

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