関連する実験動画

Updated: Mar 30, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
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Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

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薬理学的に暗い受容体GPR68とGPR65のためのアロステリックリガンド

Xi-Ping Huang1,2, Joel Karpiak3, Wesley K Kroeze1

  • 1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599-7365, USA.

Nature
|November 10, 2015
PubMed
まとめ

研究者はロラゼパムをGPR68調節剤として特定し,孤児Gタンパク質結合受容体 (GPCR) のための新しい化合物の発見を可能にしました. このアプローチは,GPCRの機能を理解し,治療法を開発するのに役立ちます.

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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay11:49

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

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