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Updated: Mar 30, 2026

Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents
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アンフォテリシンBのC3-OHはイオン伝導に重要な役割を果たします

Stephen A Davis1, Lisa A Della Ripa1, Lingbowei Hu1

  • 1Howard Hughes Medical Institute, ‡Department of Chemistry, §Department of Biochemistry, ∥School of Chemical Sciences, ⊥National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.

Journal of the American Chemical Society
|November 19, 2015
PubMed
まとめ

アンフォテリシンB (AmB) はイオンチャネルを形成する. そのC3-ヒドロキシル群を削除すると,より低い伝導率を持つ新しいチャネルが作られ,このグループはAmBチャネル機能の鍵であることを示します.

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