マンガンの代替ガドリニウム用MRIコントラスト
Eric M Gale1, Iliyana P Atanasova1, Francesco Blasi1
1The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School , 149 Thirteenth Street, Suite 2301, Charlestown, Massachusetts 02129, United States.
Journal of the American Chemical Society
|November 21, 2015
まとめ
新しいマンガン複合体は 腎臓疾患の患者にとって ガドリニウムコントラスト剤のより安全な代替品です このマンガン基の画像検出器は安定性と有効なクリアランスを示し,脆弱な集団における血管異常の診断に有望である.
科学分野:
- 医療用イメージング
- 放射化学
- 腎臓科
背景:
- コントラスト強化コンピュータトモグラフィー (CT) と磁気共鳴画像 (MRI) は,軟組織と血管の問題を診断するために不可欠です.
- 慢性腎臓病 (CKD) の患者にとって,ヨウ素とガドリニウム (Gd) ベースのコントラストメディアは安全性の危険性があります.
- 腎機能不全と適合する安全なコントラスト剤の需要は大きく満たされていない.
研究 の 目的:
- ガドリニウム代替品として,新しいマンガン (Mn) 複合体 (PyC3A) (H2O) を導入する.
- [Mn{\PyC3A}{\H2O}{\-}の安定性,緩解性,および生物学的分布を評価する.
- 強化された血栓イメージングのためのフィブリン標的マンガネスプローブ (Mn-FBP) の開発と評価.
主な方法:
- マンガンの合成と特徴付け
- 亜鉛イオンの存在による解離に対する複合性の評価
- 血と生物分布の研究における放緩性の測定
- 複合体を二機能ケラターに改変し,フィブリン特異ペプチド (Mn-FBP) に結合する.
- ネズミの動脈血栓症モデルにおけるMn-FBP結合親和性とその性能の評価
主要な成果:
- [Mn ((PyC3A)) ((H2O)))) は,ガドリニウムアナログと比較して高い安定性と解離抵抗性を表しています.
- 複合体は,商用GD剤に匹敵する緩解性を示し,腎臓/肝胆経路の混合経路で効率的に除去されます.
- Mn- FBPは,繊維素に対する高い親和性,結合時に強化された放緩性を示し,in vivoで効果的な血栓増強を提供します.
- マンガンの探査機では,24時間以内に99%以上の排泄が観察された.
結論:
- [Mn ((PyC3A)) ((H2O)))) は,腎臓不全の患者に適した新しいMRIコントラスト剤の有望な主要候補である.
- 線維素を標的とする探査機Mn-FBPは,血栓の検出のための改善されたイメージング能力を提供します.
- マンガン基のコントラスト剤は,ガドリニウムより安全な代替品です.
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