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Updated: Mar 29, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
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Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

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染色体ループドメインは,抗原受容体遺伝子の再結合を制御する

Jiazhi Hu1, Yu Zhang1, Lijuan Zhao1

  • 1Howard Hughes Medical Institute; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Cell
|November 24, 2015
PubMed
まとめ

RAG酵素はV(D) J再結合のためのDNA断裂を開始します. 新しい研究は,RAGによる多数の"非標的"断絶を特定し,リンパ球におけるDNA修復とクロマチン組織のメカニズムを明らかにしています.

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