フロントテンポラル認知症
Jee Bang1, Salvatore Spina1, Bruce L Miller1
1Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
Lancet (London, England)
|November 24, 2015
まとめ
フロントテンポラル認知症 (FTD) は,行動,実行機能,または言語に影響を与える神経変性疾患のグループで,65歳未満で一般的です. 診断の進歩により FTDと精神疾患の区別が良くなり 標的型療法への道が開けています
科学分野:
- 神経学
- 神経科学
- 遺伝学
背景:
- フロントテンポラル認知症 (FTD) は,進行的な行動,実行機能,または言語の欠陥によって特徴づけられる臨床的症候群です.
- 65歳未満の人の認知症の一般的な原因です.
- FTDの行動症状は 精神疾患を模倣し 診断を複雑にします
研究 の 目的:
- フロントテンポラル認知症 (FTD) の概要
- FTDと精神疾患の区別における診断上の課題と最近の進歩を強調する.
- FTDの分子基盤を理解することで将来の治療法への影響について議論する.
主な方法:
- FTDの臨床,イメージング,分子特性のレビュー
- FTDにおける神経病理学的発見の分析,前頭皮質と側頭皮質の変性に焦点を当てた.
- FTDの病因における遺伝子の役割の検討
主要な成果:
- FTDには,選択的な前頭皮質と側頭皮質の変性を引き起こす様々な神経病理学的な要素が含まれています.
- 遺伝的要因はFTDの発症の重要な危険因子です.
- 診断の精度が向上し,精神疾患との差異が良くなる.
結論:
- 臨床,画像,分子特徴の進歩により,FTDの診断の正確性が向上しています.
- FTDの分子基盤を理解することは,標的の治療戦略の開発に不可欠です.
- 正確な診断は,FTDを精神疾患と区別し,適切な治療を開始する鍵です.
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