抗菌剤耐性のメカニズムと要因を理解する
Alison H Holmes1, Luke S P Moore1, Arnfinn Sundsfjord2
1National Institute of Health Research Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance, and Department of Infectious Diseases, Imperial College London, London, UK.
Lancet (London, England)
|November 26, 2015
まとめ
抗菌剤耐性 (AMR) は大きな脅威です 抗菌剤耐性要因を理解し,健康,農業,環境分野にわたる包括的な多分野戦略を実施することは,効果的な抗菌剤への持続的なアクセスを確保するために極めて重要です.
科学分野:
- 微生物学
- 公衆衛生
- 環境科学
背景:
- 抗菌剤耐性 (AMR) は人間の健康と生物安全にとって重大な脅威です.
- 抗菌剤耐性の出現は自然ですが 医療,農業,環境における抗菌剤の使用によって加速されています
- AMRの伝播は,感染制御,衛生,水へのアクセス,診断,移動,移住によって影響を受けます.
研究 の 目的:
- AMRのメカニズムと要因を理解する必要性を強調する.
- 抗菌剤の選択圧力を除去するだけでは 限界があることを強調する.
- 抗生物質耐性に対抗するための包括的で多学科的な研究と統合された戦略を提唱する.
主な方法:
- AMRの発生,選択,伝播に関する既存の文献のレビュー.
- 抗生物質耐性菌の広がりと緩和戦略の効果に影響を与える要因の分析
- 複数のレベルや分野における研究ニーズを特定する
主要な成果:
- 様々な分野における抗菌剤の選択圧力は 抗菌剤耐性を著しく高めています
- 有効な抗生物質耐性低減には 選択的圧力を超える要因に対処する必要があります
- 微生物,薬物,宿主,文脈を考慮した全体的なアプローチは不可欠です.
結論:
- 抗生物質耐性を最小限に抑えるには 医療,農業,環境分野にわたる 総合的な多分野アプローチが必要です
- 効果的な抗菌剤の持続的なグローバルなアクセスを確保するには,統合された戦略が必要です.
- 抗生物質耐性メカニズムを理解し,意図しない結果に配慮したスマートな解決策を開発するには,さらなる研究が必要です.
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