貧血と早産に関する事実と人工物
M A Klebanoff1, P H Shiono, H W Berendes
1Prevention Research Program, National Institute of Child Health and Human Development, Bethesda, MD 20892.
JAMA
|July 28, 1989
まとめ
妊娠中の貧血は,特に第3 trimesterの初期に,早産と弱いリンクを示しています. この研究では,貧血が早産の主な原因ではないことが判明しました.
科学分野:
- 産婦人科と産婦人科を担当しています.
- 妊産婦・胎児医学について
- 血液学 ヘマトロジ
背景:
- 貧血は妊娠中の一般的な症状です.
- 特に多様な集団における早産におけるその役割については,さらなる調査が必要である.
研究 の 目的:
- 貧血と早産の関連性を前向きに検討する.
- 貧血が黒人女性で観察されるより高い早産率に寄与するかどうかを調査する.
主な方法:
- 35,423人の妊娠を対象とした前向きな研究.
- 貧血と貧血でない女性の間での早産発生率の比較.第3 trimesterの間に毎週.
- 妊娠25週から妊娠期までの血液濃度変化の分析,赤ん坊の出生体重と母親の人種との関係.
主要な成果:
- 妊娠3ヶ月目の初期の貧血と早産との間に弱い関連性が見られた.
- 妊娠初期における貧血は,黒人女性の早産率の増加を説明できませんでした.
- 妊娠30週後の貧血は,早産と関連していなかった.
- ヘマトクリット濃度は,25週から妊娠までの期間中,白人と黒人の両方で,分娩後の赤ちゃんを産む女性において増加した.
- 貧血と早産との関連は,28週に最も強くなり,期限が近づくにつれて減少した.
- 妊娠早産と妊娠中出産の女性の血球濃度を比較すると,偽りの投与量反応効果が生じた.
結論:
- 貧血は早産の発症の重要な要因ではありません.
- 出産中の女性の血圧を比較するなどの方法論的な問題は,結果に偏りがある可能性があります.
- 妊娠の結果に対する貧血の影響を評価する際のさらなる研究は,これらのバイアスを考慮する必要があります.
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