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Updated: Mar 29, 2026

Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay
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β細胞のインスリン分泌には,ウビキチンリガゼCOP1が必要です

Rowena Suriben1, Kelly A Kaihara2, Magdalena Paolino1

  • 1Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Cell
|December 3, 2015
PubMed
まとめ

ウビキチンリガゼCOP1は,胰腺ベータ細胞のETV転写因子を調節し,インスリン分泌と糖尿病の予防に不可欠です. これらの因子を消去すると 糖尿病を救うことが可能になり 血糖の恒常性における その役割が明らかになるのです

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