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心臓におけるβ-アドレナジック機能におけるSTAT3の重要な役割

Wenjun Zhang1, Xiuxia Qu2, Biyi Chen2

  • 1From State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (W. Zhang, X.Q., Y.T., W.S.); Riley Heart Research Center, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indianapolis, IN (W. Zhang, B.L., H.C., W. Zhu, L.Z., N.Y., D.L., L.X., Y.L., M.R., W.S.); Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City (B.C., L.-S.S.); Department of Physiology and Biophysics, Cornell University Weill Medical College, New York, NY (M.S., J.J.Z., X.-Y.H.); Department of Surgery, Indiana University School of Medicine, Indianapolis (M.W.); Department of Pharmacology, Harbin Medical University, Harbin, China (B.L.); Department of Heart Surgery, Xiangya 2nd Hospital, Central South University, Changsha, China (N.Y., L.X.); and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis (X.-Y.F.). wenjun08@gmail.com wenzhang@iu.edu wnshou@gmail.com wshou@iu.edu.

Circulation
|December 3, 2015
PubMed
まとめ

シグナルトランスデューサーとトランスクリプション3 (STAT3) のアクティベータは,心臓のβ- アドレナゲン受容体 (βAR) のシグナル伝達に不可欠です. STAT3は心臓の機能,ストレスへの適応を調節し,心不全におけるその役割を強調し,病理的な再構成を防ぐ.

キーワード:
STAT3転写因子心不全Gタンパク質結合の受容体アドレナゲン受容体

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