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TRPA1の強力でサイト選択的アゴニスト

Junichiro Takaya1, Kazuhiro Mio2, Takuya Shiraishi

  • 1Graduate School of Medicine, Kyoto University , Kyoto, Kyoto 606-8501, Japan.

Journal of the American Chemical Society
|December 3, 2015
PubMed
まとめ

研究者は,選択的にCys621に結合する強力なTRPA1チャネルアゴニストであるJT010を特定しました. この発見は,単一のシステイン改変がTRPA1チャネルを活性化することができ,さらなるメカニズム研究を支援することを示唆しています.

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