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Updated: Mar 29, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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エピテリアのIL-18均衡は,大腸炎におけるバリア機能を制御する

Roni Nowarski1, Ruaidhrí Jackson1, Nicola Gagliani1

  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Cell
|December 7, 2015
PubMed
まとめ

インタールイウキン18 (IL-18) は,腸内障壁を破壊することで潰瘍性大腸炎を誘発する. 腸内皮質細胞のIL-18シグナル伝達を遮断することで,大腸炎から保護し,コップレット細胞を保存します.

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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