精巣の生殖細胞腫瘍

Ewa Rajpert-De Meyts¹, Katherine A McGlynn², Keisei Okamoto³

¹Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark; International Center for Research and Research Training in Endocrine Disrupting Effects on Male Reproduction and Child Health, Copenhagen, Denmark.

Lancet (London, England)

|December 15, 2015

まとめ

精巣の生殖細胞腫瘍は複雑な遺伝的要因や環境要因によって生まれてくるものです流行病学,遺伝学,治療の進歩は生存者にとって希望をもたらし生活の質に重点を置いています

科学分野:

腫瘍学
発達生物学
遺伝学

背景:

精巣の生殖細胞腫瘍 (TGCTs) は,発達と腫瘍のプロセスのユニークな交差点を表します.
エチオロジーは未だに完全に理解されていないが,遺伝的傾向と並行して早期の環境被曝が重要な役割を果たすという証拠がある.
最近の全ゲノム関連研究は,遺伝的感受性の理解を大幅に進めてきました.

研究の目的:

TGCTに関する現在の知識の包括的な概要を提供する.
流行病学,遺伝学,生物学における最近の進歩を要約します
現在の治療のコンセンサス,論争,そして長期的な結果について議論する.

主な方法:

最近の疫学データのレビュー
大規模な全ゲノム関連研究 (GWAS) の結果の分析
現在の臨床試験結果と治療ガイドラインのまとめ

主要な成果:

TGCTは,遺伝的要因と環境的要因の両方を伴う,個体間での有意な変動を示します.
化学療法と放射線療法に対する高い感受性は,ほとんどの患者にとって優れた予後をもたらす.
生殖機能の保全と長期的な生活の質は,被災者の若年層にとって最も重要な問題です.

結論:

エチオロジーの継続的な研究,特に環境の影響は極めて重要です.
遅い効果を最小限に抑え生存者の生活の質を最大限に高めるための治療戦略を最適化することは継続的な優先事項です
TGCTの生物学的な基礎を理解することで,将来の治療方法が把握できます.

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