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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  2. 研究分野
  3. 生物医学と臨床科学
  4. 心血管医学と血液学
  5. 心臓病 (心血管疾患を含む)
  6. 一般的に健康な子供に診断された単純な先天性心疾患の長期全国的な追跡調査

一般的に健康な子供に診断された単純な先天性心疾患の長期全国的な追跡調査

Jørgen Videbæk1, Henning Bækgaard Laursen2, Morten Olsen2

  • 1From Department of Clinical Epidemiology, Aarhus University Hospital, Denmark (J.V., H.B.L., M.O., S.P.J.); and Department of Cardiology, Rigshospitalet, University of Copenhagen, Demark (D.E.H.). videbaek@dadlnet.dk.

Circulation
|December 20, 2015

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Implantation of Total Artificial Heart in Congenital Heart Disease
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PubMed で要約を見る

まとめ
この要約は機械生成です。

単純な先天性心疾患の患者は,より高い長期的な死亡率と心疾患に直面します. これはこれらの個人に有効な 体系的な医療フォローアッププログラムに関するさらなる研究が必要であることを強調しています

科学分野:

  • 心臓病科
  • 公衆衛生
  • 縦断的な研究

背景:

  • 単純な先天性心疾患では,定期的な追跡は推奨されません.
  • この患者の長期予後に関するデータは限られている.

研究 の 目的:

  • 単純な先天性心臓病と診断された患者の長期的な死亡率と罹患率を調査する.
  • これらの患者のアウトカムを一般患者と比較する.

主な方法:

  • 1963年から1973年の間に単純な先天性心臓病と診断された1241人の患者を対象とした全国的な追跡調査.
  • 年齢と性別を合わせた一般集団の対照群を特定した (患者1人につき10人).
  • 2013年1月1日までの死亡率,死亡原因,発病率のデータはデンマークの公的登録から収集されました.

主要な成果:

  • 患者における全死亡率の増加 (aHR,1. 9)
  • 突然の予期せぬ死は死亡率の最も一般的な原因 (40%) であった.
  • 大人の再手術と心不全の入院を含む,重大な心疾患の発生率 (aHR,5. 7) が著しく高かった.

結論:

  • 1960年代に診断された単純な先天性心疾患の患者は,長期的な死亡率と心疾患の有意な増加を経験しました.
キーワード:
生まれつきの心臓病突然の死フォローアップ研究心臓障害,先天性

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  • この発見は,体系的な医療フォローアッププログラムの有効性を評価するさらなる研究が必要であることを示唆しています.
  • 発症率
    死亡率