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Updated: Mar 28, 2026

Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
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Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C

Published on: October 14, 2022

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CTCF媒介のヒト3Dゲノムアーキテクチャは,転写のための染色体トポロジーを明らかにする

Zhonghui Tang1, Oscar Junhong Luo1, Xingwang Li2

  • 1The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06030, USA.

Cell
|December 22, 2015
PubMed
まとめ

この研究は,CCCTC結合因子 (CTCF) とRNAポリメラーゼII (RNAPII) がDNAを組織し,遺伝子の活動に影響を与える方法を示しています. ハプロタイプの変異は この構造に影響を与え 遺伝子発現と病気の感受性についての洞察を与えます

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